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Change takes time. Some symptoms of testosterone deficiency (TD) will take longer than others to improve.1 Patients may find it hard to hear that their symptoms won’t improve overnight, but setting realistic expectations with your patients can contribute to improved long-term compliance to TTh.2
The time required for TTh to improve symptoms of TD varies depending on the organ/system that is affected.1
The chart shows the time to symptom improvement and time of maximum effects for a number of sexual parameters.
| Variable | Time to symptom improvement (weeks)* | Time of maximum effects (weeks) |
|---|---|---|
| Erectile function | 3 | 52 |
| Morning erections | 3 | 6 |
| Sexual activity/ejaculations | 2 | 10 |
| Sexual interest and desire | 3 | 6 |
| Satisfaction with sex life | 3 | 12 |
*Time of first measured change (weeks)
Adapted from Saad F et al.1
Data compiled from a literature review summarising the class effects of TTh within randomised clinical trials of TD, independent of mode of delivery of testosterone. Including data from Testogel®, other testosterone gels, testosterone transdermal patch and intramuscular testosterone undecanoate injection.
The chart shows the time to symptom improvement and time of maximum effects for a number of body composition and strength variables.
| Variable | Time to symptom improvement (months)* | Time of maximum effects (months) |
|---|---|---|
| Increase muscle strength | 3 | 12 |
| Increase lean mass | 3 | 12 |
| Decrease fat mass | 3 | 24 |
| Decrease waist circumference | 3 | 24 |
| Increase exercise capacity | 3 | 12 |
| Increase bone mineral density | 6 | 36 |
| Decrease waist hip ratio | 3 | 28 |
*Time of first measured change (months)
Adapted from Saad F et al.1
Data compiled from a literature review summarising the class effects of TTh within randomised clinical trials of TD, independent of mode of delivery of testosterone. Including data from Testogel®, other testosterone gels, testosterone transdermal patch and intramuscular testosterone undecanoate injection.
The chart shows the time to symptom improvement and time of maximum effects for a number of lipids.
| Variable | Time to symptom improvement (months)* | Time of maximum effects (months) |
|---|---|---|
| Total cholesterol | 3 | 12 |
| Triglycerides | 3 | 12 |
| LDL-cholesterol | 3 | 24 |
| HDL-cholesterol | 3 | 24 |
*Time of first measured change (months)
Adapted from Saad F et al.1
Data compiled from a literature review summarising the class effects of TTh within randomised clinical trials of TD, independent of mode of delivery of testosterone. Including data from Testogel®, other testosterone gels, testosterone transdermal patch and intramuscular testosterone undecanoate injection.
The chart shows the time to symptom improvement and time of maximum effects with respect to insulin sensitivity for a number of variables.
| Variable | Time to symptom improvement (months)* | Time of maximum effects (months) |
|---|---|---|
| Insulin | 3 | 12 |
| HbA1c | 3 | 12 |
| HOMA-IR | 3 | 12 |
| Fasting glucose | 4 | 24 |
*Time of first measured change (months)
Adapted from Saad F et al.1
Data compiled from a literature review summarising the class effects of TTh within randomised clinical trials of TD, independent of mode of delivery of testosterone. Including data from Testogel®, other testosterone gels, testosterone transdermal patch and intramuscular testosterone undecanoate injection.
Encourage your patients to review their symptoms using the Ageing Males’ Symptom (AMS) scale in the T Track app and monitor their progress over time.
T Track app available for both iOS and Android phones.
References
TES/2022/045. February 2023.